Drug Interaction:
Beta-adrenergic blockers include- Atenolol, Acebutol, Betaxolol, Bisoprolol,Cartelol,Esmolol,Labetatol,Metoprolol, Nadolol,Penbutolol, Pinodol, Propranolol,
Solatol, Timolol,
Refer - Atenolol
Marked hypertension and tachycardia with adrenaline.
Reduced heart rate and ouput with anaesthestic agents.
Rebound hypertension due to abrupt withdrawal of clonidine potentiated.
Severe bradycardia may occur with digitalis and cal chnl blckrs(especially with impaired
left ventricular function).
Concurrant use with chlorpromazine results in blood levels of both drugs and additive
hypotensive effect.
Elevated blood levels with cimetidine.
Hypotensive effect reduced by indomethicin.
Increased episode of hypoglycaemia and masking of hypoglycaemic symptoms in diabetes.
Reduced efficacy in smokers.
Inhibit tachycardia mediated by vasodilators (hydralazine,minodoxil).
Additive effect with other anti-hypertensives and diuretics.
Indication:
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Propananol 40mg SR pellets 16-03-2010
+ Flurazine 5mg /10mg capsules
For the prophylaxis of migraine
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Propranol 40mg + Feb 1980
Hydrallazine 25mg tablet
2.Propranol hcl 40mg + Oct 1982
HCTZ 25mg tablets
3.Propranol hcl 80mg + Oct 1982
Bendrafluzide 2.5mg capsule
Cardiac arrhythmias.
Beta-adrenergic blockers include- Atenolol, Acebutol, Betaxolol, Bisoprolol,Cartelol,Esmolol, Labetatol,Metoprolol, Nadolol,Penbutolol, Pinodol, Propranolol, Solatol, Timolol, Refer - Atenolol
Adverse Reaction:
Severe bradycardia,hypotension and shock in patients with pre-existing cardiac disease. Sudden withdrawal may be fatal in patients with IHD and MI.
Cold extremities, insomnia, lassitude, nausea, constipation/diarrhoea,impotence. CNS disturbances in higher doses(240mg/daily), fatigue, dizziness, insomnia, vivid dreams and mood alterations.
Contra-Indications:
Sinus bradycardia,heart block greater than 1st degree,cardiogenic shock,bronchial asthma, overt CCF(unless results fromtachy-arrhythmias treatable with immediate release propranolol.
Special precautions:
While swithching over from conventional to sustained release propranolol,at the end of 24 hours titration of dose may suggest need for increased dosage as the long acting propranolol produces lower serum levels. Reduce dosage over a peroid of several weeks,if reqd.IHD, CCF, renal or hepatic dysfunction.
Dosages/ Overdosage Etc:
Indications:
Cardiac arrhythmias,myocardial infaction,,hypertrophic stenosis, phenocromocytoma, hypertension, angina pectoris,essential tremor.
Dosage:
Initial - 40mg Bid or 80mg once daily.usual range- 120 to 240mg/day divided 2 or 3 times a day.Maximum- 640mg/day
Missed dose-
1. If you are using this medicine regularly and you miss a dose, use it as soon as possible.
2. Then use the remaining dose for that day at regularly spaced intervals.
3. Do not double doses.
Patient Information:
Refer - Atenolol
Pharmacology/ Pharmacokinetics:
Refer - Atenolol- Beta adrenergic blocker
Interaction with Food:
Absorption may be dealyed without affecting peak levels. Bioavailability increased. Sustained release forms not affected.
Pregnancy and lactation:
Refer- Atenolol - Beta adrenergic blocker
Manufacturer Details