Drug Interaction:
Interacting Drugs - summary
Zinc salts +
Fluroquinolones GI absorption and serum levels of some fluoroquinolones decreased, possibly resulting in a decreased anti-infective response. Avoid simultaneous use,asdminister 2 to 4 hours after the fluoroquinolones
Tetracycline GI absorption and serum levels of tetracyclines decreased, possibly resulting in a decreased anti-infective response. Doxycycline does not appear to be affected
Drug/Food interactions- Bran products (including brown bread) and some foods( eg. protein, phytates, some minerals) may decrease zinc absorption
Indication:
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
ZnSO4 0.660mg Hepatahydrate eq.to 08-101994
elem. Zn 0.15mg +
CuSO4 0.236mg Pentasulphate eq to
elem Copper 0.06mg +
Chromic chloride 1.83mg anhydrous eq to
elem Chromium 0.6mg +
MnSo4 0.047mg monohydrate eq.to
elem Manganese 0.25mg +
Benzyl alcohol 1% preservative
Trace metal additive infusion (TMA infusion)
Dietary supplement
Interacting Drugs - summary
Zinc salts +
Fluroquinolones decr GI absorption and serum levels of some fluoroquinolones decreased, possibly resulting in a decreased anti-infective response.
Avoid simultaneous use,asdminister 2 to 4 hours after the fluoroquinolones Tetracycline decr GI absorption and serum levels of tetracyclines decreased, possibly resulting in a decreased anti-infective response. Doxycycline does not appear to be affected
Adverse Reaction:
Nausea, vomting
Contra-Indications:
Pregnancy
Special precautions:
Do not exceed the prescribed dosage, will cause emesis if administered in single 2 g doses.
Warnings
Excessive intake- in healthy persons amy be deleterious. Even healthy men who ingested 150mg twice daily for 6 weeks showed significant impairment of lymphocyte and polymorphonuclear leukocyte functions and a significant decrease in high density lipoproteins (HDL)
Pregnancy- since zinc deficiency is very rare, the routine use of zincsupplementation during pregnancy is not recommended. However a dietary zinc intake of 15mg/day is recommended.
Lactation- breast milk concentration of zinc decrease over time following delivery, extra dietary intake of zinc of 7mg/day for the first 6 months of lactation and 4mg/day during the second 6 months are recommended.
Dosages/ Overdosage Etc:
Indications:
Dietary supplement Dosage: Average adult dose is 25 to 50mg zinc daily
Overdosage- Symptoms Nausea, vomiting, dehydration, restlessness sideroblastic anemia (secondary to zinc- induced copper toxicity)
Treatment
1. Reduce dosage or discontinue to continue symptoms
Missed dose
1. If you taking zinc supplements for one or more days threr is no cause for concern, since it takes some time for your body to become low in zinc.
2. However, if your health care professional has recommended that you take zinc, try to remember to take it as directed every day
Patient Information:
If GI upset ocurs ,take with food, but avoid foods high in calcium, phosphorus.
Ref - USP PDI Vol II 17th Edition (1997)
ZINC SUPPLEMENTS - SYSTEMIC
1.Allergies-
Tell your doctor if you are allergic to any other substances such as foods,
preservatives or dyes.
2.Pregnancy-
It is especially important that you are receiving enough vitamins and minerals
when you become pregnant and that you continue to receive the right amount
of vitamins and minerals throughout your pregnancy. The healthy growth and
development of the fetus depend upon a steady supply of nutrients from the
mother.
There is evidence that low blood levels of zinc lead to problems in pregnancy
or defects in the baby. However, taking large amounts of dietary supplements
may be harmful to the mother and/or fetus and should be avoided.
3. Breast-feeding-
It is important that you receive the right amounts of vitamins and minerals
needed for the baby to grow properly. However, taking large amounts of
dietary supplements while breast-feeding may be harmful to the mother
and/or baby and should be avoided.
4.Children-
Problems in children have not been reported with intake of normal daily
recommended amounts.
5.Older adults-
There is some evidence that the elderly may be at risk of becoming
deficient in zinc due to poor selection, decreased absorption of zinc by
the body, or medicines that decrease absorption or increase loss
of zinc from the body.
6. Other medicines-
When you are taking zinc supplements it is especially important that your
doctor know if you are taking any of the following-
Copper supplements or
Tetracycline - use with zinc supplements may cause these copper
supplements or tetracycline to be less effective, zinc supplements
should be given 2 hours after copper supplements or tetracycline
7. Other medical problems-
The presence of other medical problems may affect the use of zinc
supplements. Make sure you tell your doctor if you have any other
medical problems especially-
Copper deficiency - zinc supplements may make the condition worse.
Pharmacology/ Pharmacokinetics:
Pharmacology:
Normal growth and tissue repair depend upon adequate zinc. Zinc acts as an integral part of several enzymes important to protein and carbohydrate metabolism.
Pharmacokinetics:
Zinc salts are poorly absorbed from G I tract; 20 to 30% of dietary zinc is absorbed
Interaction with Food:
Drug/Food interactions- Bran products (including brown bread) and some foods( eg. protein, phytates, some minerals) may decrease zinc absorption
Pregnancy and lactation:
Pregnancy:
Routine use of zinc supplementation during pregnancy is not recommended.
Lactation:
Breast milk concentrations of zinc decreases over time following delivery; extra dietary intake of zinc of 7mg/day for the first 6 months of lactation and 4mg/day during the second 6 months are recommended.
Manufacturer Details
About Us