Angiotensin II Receptor Antagonists- Candesartan, Eposartan, Irbestan, Losartan metabolite, Olmesatran, Telmistran, Valsartan

Aspirin,NSAIDs, K -Sparing diuretics, K -supplements, lithium,

Angiotensin II Receptor Antagonists-

Candesartan, Eprosartan, Irbestan, Losartan metabolite, Olmesatran, Telmistran, Valsartan

Adverse Reactions-
 

IRBESARTAN

 CNS  - 

  Dizziness, Headache > 1%,Fatigue 4%,  Anxiety/nervousness >1% Depression  < 1%
 
 GI  - 

 Diarrhea  3%, Dyspepsia /heartburn 2%, Nausea/vomiting >1%  Abdominal pain >1%     
 
  Musculoskeletal- 

   Pain  >1%Trauma 2%

  Respiratory -  

  Upper Res tract infn  9% Cough  3% Sinus disorder >1% Pharyngitis >1% Rhinitis >1%
  Influnz  symptoms >1%

  Miscellaneous - 

 Edema >1%  Chest pain  >1% Rash >1%   Tacycardia >1%  Urinary tract infn >1%
                            

Pregnancy, lactation primary aldosteronism

Special precautions- Correct volume and or salt fdepletion before starting therapy Renovascular hypertension

Renal impairment

Heart failure

Monitor serum potassium and creatinine levels

Aortic or mitral valve stenosis, Ventricular dysfunction, cardiac arrhythmias, severe hepatic impairment,

Obstructive hypertrophic cardiomyopathy

Recent kidney transplant, haemodialysis.

Renal artery stenosis

Elderly

Type ll diabetes with renal disease

Indication-

Hypertension

Renal disease in hypertensive Type ll diabetes

Dosage

Initially 150mg once daily

Lower starting dose in volume/sodium depletion, haemodialysis increase if necessary to 300mg once daily or add other antihypertensives agent

Elderly over 75 years-  Initially 75mg once daily then titrate according to responses

Renal disease -Initially  150mg once daily, titrate to 300mg once daily for maintenance

Angiotensin II Receptor Antagonists-

Candesartan, Eposartan, Irbestan, Losartan metabolite, Olmesatran, Telmistran, Valsartan 

Contra-indicated in pregnancy and lactation