DESLOR
Manufacturer Details
SUN PHARMA
Compositions:
Desloratadine 5mg tablets,
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Strength
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Rate
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Packing Style
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5mg
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85.00
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10s tablets
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List of Related Indications:
- Allergic conditions
- Chronic idiopathic urticaria
- Seasonal allergic rhinitis
List Of Drugs:
- Desloratadine@ Anti-histamine
Indication Type Description:
Pharmacology/ Pharmacokinetics
Drug Interaction:
No clinically important drug interactions have been identified in clinical trials of desloratidine. Erythromycin and ketoconazole - although these drugs inhibit the metabolism of loratidine , no adverse clinical effects have been noted.
Indication:
Allergic Rhinitis
Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
Desloratidine Anti-Allergic 30-10-2001
Allergic Rhinitis
Antihistamines Include: First Generation ( Non-selective ) Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine Phenothiazines- Methidilazine, Promethizine, trimeprazine Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine Refer - Chlorpheniramine maleate
Adverse Reaction:
Headache, dry mouth and fatigue.
Contra-Indications:
Hypersensitivity to desloratidine or to loratidine.
Special precautions: It should not be used in pregnancy unless the potential benefits outweigh the risks. As desloratidine is excreted into breast milk, it is not recommended for use in breastfeeding women.
Desloratidine should be used with caution in patients with severe renal impairment.
Dosages/ Overdosage Etc:
Allergic disorders Adults and adolescents( 12 years and over)- 5mg daily with or without a meal.
Patient Information:
Antihistamines Include: First Generation ( Non-selective ) Ethanolamine- Carbinoxamine. Clemastine, Diphenhydramine. Ethylenediamines- Pyrilamine, Triplennamine Akylamines- Brompheneramine, Chlorpheniramine, Dexchlor pheniramine,Pheniramine,Triprolidine Phenothiazines- Methidilazine, Promethizine, trimeprazine Piperidines- Azatadine, Cyproheptadine, Phenindamine Miscellaneous- Astemazole, Loratadine, Terfenadine Second Generation ( Peripherally selective ) Phthalazinone - Azelastine Piperazine - Cetrizine Refer - Chlorpheniramine maleate
Pharmacology/ Pharmacokinetics:
Pharmacology:
Desloratidine is a long-acting, non-sedating, selective peripheral hisrtamine H2 receptor antagonist. It is the major active metabolite of the parent drug loratidine. Desloratidine acts by inhibiting the release of pro-inflammatory mediators from human mast cells/basophils
Pharmacokinetics:
Desloratidine is well absorbed with maximum plasma concentrations within about 3 hours; the terminal elimination half-life is approximately 27 hours Food does not affect the extent of absorption. Desloratidine is primarily metabolised by hydroxylation and excreted mainly in the urine as metabolites. There is no evidence of clinically relevant drug accumulation following once daily dosing of desloratidine(5mg to 20mg ) for 14 days..
Interaction with Food:
Can be taken with or without a meal.
Pregnancy and lactation:
It should not be used in pregnancy unless the potential benefits outweigh the risks. As desloratidine is excreted into breast milk, it is not recommended for use in breastfeeding women.
