ENDOXAN -ASTA


Brand:
ENDOXAN -ASTA

Manufacturer:
ZYDUS CADILA GERM REM

  
Compositions:
Cyclophosphamide 50mg tablets, Cyclophosphamide 200mg/500mg /1g per vial injection,
  
Strength Rate Packing Style
50mg 38.65 10s tablets
200mg per vial 60.30 1 injection
500mg per vial 72.20 1 injection
1g per vial 158.73 1 injection

List of Related Indications:
  • Lymphomas

List Of Drugs:
  • Cyclophosphamide ( ** ) @ nitrogen mustard - Alkylatg agent

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

   

Drug Interaction:

Alkylating Agents Includes-

Mechlorethamine ,Chlorambucil, Melphalan, Ifosamide,Cyclophosphamide, Urasil Mustard,
Lomustine, Carmustine, Streptozocin, Thiotepa, Busulfan, Pipobroman, Cisplatin, Carboplatin
 


Interacting drugs- summary

+  cyclophosphamide-

Chloramphenicol
Cyclophosphmide  half-life  increased, metabolite conc decreased

Thiazide diuretics
 antineoplastic-induced leukopenia    prolonged

Allopurinol
myelosuppressive  effects of cyclophosphamide may be enhanced, possibly increasing the risk of bleeding or infection

Chloramphenicol + Cyclophosphamide
 decreased or delayed activation of cyclophosphamide may occur, although it is 
 unclear if a significant decrease in its effects would occur.

Doxorubicin
exacerbation of cyclophosphamide -induced hemorrhagic cystitis and      
 enhancement of 6-mercaptopurine have occurred.

Cyclophosphamide +

Digoxin
Digoxin serum level reduced

Succinyl choline
 neuromuscular blockade  prolonged

Anticoagulants
May increase the anticoagulant efect of warfarin or anisindione
 The risk of bleeding is increased. The mechanism of action
  is unknown or complicated.