Requirement of insulin may be reduced requiring careful blood glucose monitoring.

Reduction in cyclosporine bioavailabilty,delay in absorption of cimetidine.

Carcinoid tumors,intestinal peptide tumors.

Local pain, stinging, tingling at site of injection can occur, anorexia, nausea, vomiting, abdominal pain, bloating, flatulance, loose stools,

Increased incidence of gallstones, epigastric pain and tenderness.

Hypersens to the drug or any of its components.

Special precautions:

Renal disease, risk of gall bladder disease, diabetes, hypothroidism,

pregnancy and lactation.

Indications:

Carcinoid tumors,intestinal peptide tumors.

Dosage:

Do not use if particulate or discolouration are observed. 100 to 60mcg/day in 2 or 3 divided doses for 2 weeks.(median average dose is 450mcg/day).

OCTREOTIDE - Give careful instruction on sterile SC injection technique to patients and other persons who may administer octreotide.

1. Allergy- Tell your docter if you are allergic to octrotide or any other food substances or preservative or dyes.

2. Pregnancy- studies not done on humans. However studies on rats and rabbits have not shown that octreotide causes birth defects or other problems even when given in doses several times the human dose.

3. Breast feeding- not known whether octrotide pases into breast milk. However octreotide has not shown to cause problems in nursing babies.

4. Children- medicine has not been tested in children as young as 1 month of age and has not shown to cause different side effects or problems than it does in adults.

5. Older adults- has been used in persons up to 83 years of age and has not been shown to cause different side effects or problems in older people than it does in younger adults.

6. Other medicines- whe you are takng ostreotide it is especially important your doctor knows if you are taking any of the following- Antidiabetics- oral or Glucogon or Insulin -ostreotide may cause high or low bood sugar, your doctor may need to change the dose of your diabetic medicine Growth hormone- otreotide may cause high or low blood sugar, your doctor may need to change the dose of this medicine.

7.Dosing- dose of octrotide amy diffeentfor different patients. Follow your doctors orders or directions on the label.

8. Missed dose- if you miss a dose take it as soon as possible. However if it is almost time for time for the next dose, skip the missed dose and go back your regular schedule.

9. Storage- Keep out of reach of children Store away from direct heat and direct light Do not keep outdated medicines or medicines no longer in use. Make sure to keep any discarded medicine from reach of children

Pharmacology:

Octreotide acetate is a long-acting octapeptide with pharmacologic actions similar to those of natural hormone somatostatin. It is more potent inhibitor of growth hormone. Like somatostatin it suppresses LH response to GnRH,decreases splanchnic blood flow and inhibits release of serotonin, gastrin, vasoactive intestinal peptide scretion, motilin and pancreatic polypeptide.

Pharmacokinetics:

After SC injection octreotide is absorbed rapidly and completely from the injection site.Peak concentration of 5.5ng/ml(100mcg dose) were reached 0.4hours after dosing. IV and SC doses are bioequivalent.

Not applicable

Pregnancy:

Use during pregnancy only if clearly needed

Lactation:

Excercise caution when octreotide is administered to a nursing woman.