Adverse Reaction:
Severe liver damage and fulminant hepatitis. Hepatotoxicity (Hepatomegaly, splenomegaly, and jaundice may develop and in rare case fulminating acute yellow atrophy and death). Anorexia, nausea, vomiting, Arthalgia, malaise, Fever, hyperuricaemia, Abnormal LFT,raised plasma fibrinogen. Rarely photosenstivity and skin rashes. Interferes with urinary ketone estimations.
Other Information:
For Availability/supplies
Contact -
1.Indian Drug Manufacturers Association (IDMA)
Phone- 022- 24944624/ 24974308
Fax- 022- 24950723
Email- idma@vsnl.com
Website: www.idma-assn.org
2.Bulk Drug Manufacturers Association (India)(BDMA)
Phone - 040-23703910/ 23706718
Fax- 040-23704804
Email- info@bdmai.org
Website: www.info@bdmai.org
Patient Information:
1.Notify physician,if they experience, fever, loss of appetite, malaise, nausea
and vomiting, darkened urine, yellowish discolouration of skin and eyes,
pain or swelling of the joints.
2.Complete full course of therapy. Do not miss any dose.
Ref - USP PDI Vol II 17th Edition (1997)
PYRAZINAMIDE - Systemic
1.Allergies-
Tell your doctor if you have ever had any unusual or allergic reaction to
pyrazinamide or to ethionamide , isoniazid, or niacin,. Also tell your
healthcare care professional if you are allergic to any other
substances such as foods. preservatives or dyes.
2.Pregnancy-
Studies have not been done in humans or animals.
3. Breast-feeding-
Pyrazinamide passes into breast milk in small amounts.
.
4.Children-
Pyrazinamide has been used in children, and in effective doses the
medicine has not been shown to cause different side effects or
problems than it does in adults.
5.Older adults-
Although there is no specific information comparing use of pyrazinamide
in the elderly with use in other age groups, this medicine is not expected to
cause different side effects or problems in older people than it does in
younger adults.
6. Other medicines-
Tell your doctor if you are using any other prescription or non-prescription
(Over-the counter) OTC medicine.
7. Other medical problems-
Make sure you tell your doctor if you have any other medical problems
especially-
Gout - pyrazinamide worsen or cause a gout attack in patients with a
history of gout
Liver disease- patients with severe liver disease who take pyrazinamide
may have an increase in the side effects
