Amikacin ( *** ) - @ Aminoglycosides

Drug Name:
Amikacin ( *** ) - @ Aminoglycosides

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

   

Drug Interaction:

Aminoglycosides include-

Amikacin, Gentamicin, Kanamycin, Netlimicin, Streptomycin,Tobramycin,
 Neomycin,  Paromomycin,

Refer Amikacin


Drug interactions - summary
 

AMINOGLYCOSIDES -PARENTRAL


+ Aminoglycosides

Cephalosporins/ Enflurane/ Methoxyflurane / Vancomycin


Risk of nephrotoxicity increase above that with   aminoglycosides alone.
 Monitor patients. With cephalosporins, bacterial activity against
certain pathogens enhanced
 
Indomethicin  IV 


 In preterm infants, the use of indomethicin for closure of  patent
  ductus arteriosus resulted in aminoiglycosides accumulation in            
   one study

Loop diuretics 


Auditory appears to increase during concomittant use. Hearing
 loss of varying degrees may occur it may be irreversible.
  Monitor patients

Penicillins


Synergism of these agents is well documented: however certain
 penicillins may inactivate certain aminoglycosides. The problem
  may be greatest in vitro

Penicillin parentral  +   Aminoglycosides parentral


 Although used together for synergistic action,certain penicillins may               
 inactivate certain aminoglycosides in vitro. Do not mix in the
  same IV solution. Oral Neomysin may reduce the serum
  concentration of  oral penicillin.


Aminoglycosides +

Neuromuscular blockers,/Depolarising  


 Neuromuscular blocking effects are enhanced by aminoglycosides
  Prolonged respiratory depression  occur
     

Polypeptides antibiotics


 Concurrent use of these agents may increase the risk of respiratory
  paralysis and renal dysfunction

Pancuronium 


 Parentral/intraperitoneal administration of high doses of certain antibiotics 
 produce neuromuscular block on its own.
 
Atracurium 


These medications enhance the neuromuscular blocking action of atrcurium.
 
Vercurinium 


Parentral/intraperitoneal admininistration of  of high doses of certain antibiotics
 intensify or produce neuromuscular blockade on their own.
 Possibility of unexpected prolongation of neuromuscular block

Pipecuronium


Parentral/Peritoneal administration of high doses of cetain antibitotics
  intensify or  produce neuromuscular blockade on their own. If these or other
 consider prolongation of  neuromuscular block, a possiblity.

Colisimethate


Concurent use increase the risk of respiratory paralysis and renal
 dysfunction
 
Polymixin B 
concurrent use  increase the risk of respiratory paralysis
  and renal dysfunction

Bacitracin 
 concurrent use  increase risk  of respiratory collapse
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