Drug Information

Drug Interaction:

Drugs covered:
                                  1st generation          2nd generation              3rd generation
.                                  Cephalexin               Cefaclor                       Cefixime
                                   Cefadroxil                Cefamandole                 Cefoperazone
                                   Cephadrine              Cefotoxitin                    Cefotaxime
                                   Cephalothin             Cefuroxime                    Ceftizoxime
                                   Cephapirin               Cefonicid                      Ceftriaxone
                                   Cefazolin                 Cefmetazole                   Ceftazidime
                                                                 Cefotetan                       Ceftibuten
                                                                  Cefprozil                        Cefepime
                                                                  Cefpodoxime
                                                                  Loracarbef
Refer Cephalosporins

Concomittant administration of high doses of antacids like sodium bicarbonate or Aluminium hydroxide or H2 blocks, decreases the paek plasma levels by 24- 42% and the extent of absorption by 27- 32%.

Oral anticholinegics delay the attainment of peak plasma levels but not affect the extent of absorption. Renal excretion is inhibited by probenecid, resulting in increase in AUC and also peak Cefpodoxine levels

Indication:

Approved by FDA on August, 1992

U.S.FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08

Drug name Indication Date of Approval

66. Cefpodoxime 50mg 31-01-08

+ Clavulanic acid 31.25mg dispersible tablet

& dry syrup

(Addl.Stgth)

Same as approved

U.S FDA APPROVED DRUGS DURING 2007

116. Cefpodoxime (as Proxetil) 30-07-07

(100mg/200mg) +

Clavulanic acid 962.5/125mg) tablet

For LRTI,URTI, and UTI

Approved by (DCI) Drug Controller GENERAL - India For Marketing

(Ref- IDMA Publication)

Name of Drug Indication Date of Approval

1. Cefpoxiime For bronchitis September 1997

Proxetil

2. Cefpoxime Proxetil 14-03-1996

Antibacterial for use in adult and children with mild to moderate

infections invloving ,URT, LRT skin and soft tissue,UTI ,

sexually transmitted infections

3.Cefpodoxime proxetil 30.07-2007

100mg/200mg + Clavulanic acid

62./125mg tablet

For LRTI,URTI,and UTI

4. Cefpodoxime 06-08-2010

100/200mg + Dicloxacin ER 500mg/500mg

For the treatment of Lower RI, Skin and Soft Tissue, Bone and

Joint Infections and ENT Infections in Adult patients prone to

antibiotic induced diarrhoea

5. Cefpodoxime 50mg + Clavulanic acid 31.01-2008

31.25mg Dispersible tablet & dry syrup

Addl.Strgth.

Same as approved

6. Cefpodoxime IP 16-04-2011

100mg/100mg/200mg/200mg + Ofloxacin

IP 100mg/200mg/100mg/200mg tablets

For thetreatment of Lower and Upper Respiratory tract

infection and Typhoid fever in adults only

FIXED DOSE COMBINATIONS APPROVED BY DCG(I)

FROM JANUARY 1961 TILL NOVEMBER 2014

Name of Drug Indication Date of Approval

1.Cefpoxime 100mg + 31-01-2008

Clavulanate Potassium 62.5mg Dispersible tablet/

Dry syrup

For LRTI, URTI, and UTI

2.Cefpodoxime 100mg + 29-11-2012

Ofloxacin 100mg dispersible tablet

Addl.Dosage Form

For the treatment of Lower and upper respiratory tract infection and

Typhoid fever in adults only

Drugs covered:

1st generation 2nd generation 3rd generation

. Cephalexin Cefaclor Cefixime

Cefadroxil Cefamandole Cefoperazone

Cephadrine Cefotoxitin Cefotaxime

Cephalothin Cefuroxime Ceftizoxime

Cephapirin Cefonicid Ceftriaxone

Cefazolin Cefmetazole Ceftazidime

Cefotetan Ceftibuten

Cefprozil Cefepime

Cefpodoxime

Loracarbef

Refer Cephalosporins

Adverse Reaction:

Pseudomembrane colitis, Anaphylactic shock, Acute liver injury in utter exposure with miscarriage. Purpuric nephritis, Pulmonary infiltrate with eosinophilia Eye lid dermatitis.

Contra-Indications:

Hypersensitivity to the drug

Dosages/ Overdosage Etc:

Approved by FDA on August, 1992

Indications: Lower respiratory tract infection

Dosage: Adults- total daily dose- 400mg given 200mg every 12 hours for 14 days

Children- Total daily dose - 10mg/kg/day given 10mg/kg/every 24 hours for10 days

Patient Information:

Refer cepholosprins

Pharmacology/ Pharmacokinetics:

Refer cephalosprins

Interaction with Food:

Take after meals

Pregnancy and lactation:

Refer cepholosprins

Cefpodoxime Proxetil - @ Cephalosporins- Second generation- (FDC-List) (July 2007)

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation