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Updated On: 27-02-2024

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Metolazone - @ -Thiazide and related diuretics- (FDC- List )- (Apr 2003)

Drug Name:
Metolazone - @ -Thiazide and related diuretics- (FDC- List )- (Apr 2003)

List Of Brands:

ZAROXOLYN *
LAZON
METOZ
METORAL

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pharmacology/ Pharmacokinetics

Pregnancy and lactation

Drug Interaction:

Thiazides and related diuretics include-

Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide,
Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide

Refer Hydrochlorthiazide- Thiazide and related diuretics

Indication:

U.S.FDA APPROVED DRUGS FROM 01-01-08 TO 31-12-08

Drug name Indication Date of Approval

138. Metalazone 2.5mg 28-05-08

+Losartan potassium 25mg/50mg tablets

For hypertension in patients whose blood pressure

is not adequately controlled by monotherapy

139. Metalazone 2.5mg 28-05-08

+ Ramipril 2.5mg/5mg

For essential hypertension in adult patients

whose blood pressure is not adequately controlled

by monotherapy

184. Metolazone 25-08-08

+ Spironolactone FC tablets (2.5/5mg+50mg)

(Addl.stgth)

For the treatment of odema associated with congestive

heart failure, cirrhosis and nephtitis syndrome

Approved by (DCI) Drug Controller GENERAL - India For Marketing (Ref- IDMA Publication)

Name of Drug Indication Date of Approval

1.Metalazone Diuretic 23-04-2003

2.Metalazone 25-08-2008

+ Spironnolactone FC tablets

2.5mg +50mg

For the treatment of oedema associated with congestive heart failure,

cirrhosis and nephrotic syndrome

3.Metalozone 2.5mg 28-05-2008

+ Losartan potassium 25mg/50mg tablets

For Hypertension in patients whose blood pressure is not adequately

controlled in monotherapy

4.Metalozone 2.5mg 28-05-2008

+ Ramipril 2.5mg/5mg

For essential hypertension in adult patients whose blood pressure

is not adequately controlled on monotherapy

Edema, hypertension

Thiazides and related diuretics include-

Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide,
Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide

Refer Hydrochlorthiazide- Thiazide and related diuretics

Adverse Reaction:

Refer Chlorthiazide- Thiazide and related diuretics

Contra-Indications:

Refer Chlorthiazide- Thiazide and related diuretics

Dosages/ Overdosage Etc:

Date of Approval 2003

Indication:

Edema, hypertension

Dosage:
Individualise dose.

Zaroxolyn-
Mild to moderate hypertension- 2.5 to 5mg daily
Edema of renal disease- 5 to 20mg oncecdaily
Edema of cardiac failure- 5 to 20mg once daily
Brands are not bioequivalent. Do not interchange brands

Patient Information:

Thiazide diuretics

1. May cause GI upset, may be taken with food
2. Drug will initially increase urination which should subside after a few weeks, take early during the day or as
    directed
3. Notify physician, if muscle pain,weakneess or cramps, nausea, vomiting, restlessness, excess thirst,
    tiredness, drowsiness, increased heart rate or pulse, diarrhea, or dizziness occurs
4. May cause photosensitivity (sensitivity to sunlight). Avoid prologed exposure to the sun and other
    ultraviolet light.
    Use sunscreens and wear protective clothing until tolerance is determined
5. May increase blood sugar levels in diabetes
6. Do not drink alcohol or take other medications without physicians approval, this includes
    nonprescription medicines for appetite control, asthma, colds, cough,hay fever or sinus
7. Do not interrupt , discontinue or adjust the dose, even if feeling well. Follow physicians instruction
    regarding missed dose.

Pharmacology/ Pharmacokinetics:

Pregnancy and lactation:

Refer Chlorthiazide- Thiazide and related diuretics

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