Gliclazide@( ** )-Hypoglycemic agent-(FDC- List )- (Nov 1988)
Drug Name:Gliclazide@( ** )-Hypoglycemic agent-(FDC- List )- (Nov 1988)
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Patient Information
Drug Interaction:
Sulfonylureas- include-
First generation - Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide
Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide
Refer Chlorpropamide
Interacting drugs - summary
+ Metformin
Alcohol
Alcohol potentiates the effect of metformin on lactate metabolism.
Warn patients against excessive alcohol intake, while receing metformin
Cationic drugs
Cationic drugs( eg amiloride, digoxin, morphine, procainamide,
quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin) eliminated by renal tubular secretion, have the potential for interaction with
metformin careful patient monitoring and dose adjustment of metformin recommended
Cimetidine
Cimetidine caused a 60% increase in peak metformin plasma and
whole blood concentrations and a 40% increase in plasma and
whole blood AUC
Furosemide + Metformin
Furosemide increased the metformin plasma and blood Cmax and
blood AUC , without any significant change in metformin renal clearance
Metformin +Furosemide
When administered with metformin, the Cmax and AUC of
furosemide were smaller than administered alone, and the terminal
half-life decreased, without any significant change in furosemide
renal clearance.
Iodinated contrast material
Parentral contrast studies with iodinated materials can lead to
acute renal failure and have been associated with lactic acidosis
in patients receiving metformin. Therefore withhold metformin for
at least 48 hours prior to and 48 hours subsequent to the procedure
Nifedipine
Co-administration increased plasma metformin Cmax and AUC
respy, and increased the amount excreted in the urine. Nifedipine
appears the absorption of metformin