Gliclazide@( ** )-Hypoglycemic agent-(FDC- List )- (Nov 1988)

Drug Name:
Gliclazide@( ** )-Hypoglycemic agent-(FDC- List )- (Nov 1988)

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

   

Drug Interaction:

Sulfonylureas- include-

      First generation -  Acetohexamide, Chlorpropamide, Tolazamide, Tobutamide
      Second generation - Glipizide, Glyburide ( Glibenclamide ), GlimepIride,Gliclazide
     
     Refer Chlorpropamide
 
Interacting drugs - summary
 
+  Metformin 
 
Alcohol
   Alcohol potentiates the effect of metformin on lactate metabolism.
   Warn patients against excessive alcohol intake, while receing metformin
                                           
Cationic drugs 
  Cationic drugs( eg amiloride, digoxin, morphine, procainamide,
   quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin)                                      eliminated by renal tubular secretion,  have  the potential for interaction with 
     metformin careful patient monitoring and dose adjustment of metformin recommended
 
Cimetidine
    Cimetidine caused a 60% increase in peak metformin plasma and 
     whole blood concentrations and a 40% increase in plasma and
     whole blood AUC  
 
Furosemide  + Metformin   
  Furosemide increased the metformin plasma and blood Cmax and    
  blood AUC , without any significant change in metformin renal clearance
 
Metformin +Furosemide 
  When administered with metformin, the Cmax and AUC of 
   furosemide were smaller than administered alone, and the terminal
    half-life decreased, without any significant change in furosemide 
     renal clearance.
 
Iodinated   contrast   material 
    Parentral contrast studies with iodinated materials can lead to 
     acute renal failure and have been associated with lactic acidosis     
    in patients receiving metformin. Therefore withhold metformin for 
    at least 48 hours prior to and 48 hours subsequent to the procedure                                       
 
Nifedipine
    Co-administration increased plasma metformin Cmax and AUC 
     respy, and increased the amount excreted in the urine. Nifedipine 
     appears the absorption  of metformin