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Updated On: 27-02-2024

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Uracil Mustard - Nitrogen mustard - @ - Alkylating agents

Drug Name:
Uracil Mustard - Nitrogen mustard - @ - Alkylating agents

List Of Brands:

URACIL MUSTARD *

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation

Drug Interaction:

Reports not available

Indication:

Pallliative treatment of symptomatic chronic lymphocytic leukemia Non - Hodgkins lymphomas

Adverse Reaction:

Haematologic- dose related bone marrow depression, leukopenia, thrombocytopenia anemia

GI- nausea, vomiting, or diarrhea of varying severity ( dose related )

Dermatologic- pruritus, dermatitis, hair loss, ( may or may not be dose related )

CNS- nervousness, irritability, depression ( may or may be dose related )

Miscellaneous- hepatotoxicity (rare ) amenorrhoea, azoosperma

Contra-Indications:

Severe leukopenia or hrombocytopenia

Warning

Haemotologic effects - monitor patients to avoid irreversible damage to bone marrow uracil mustard has a cumulative toxic effect against the hemotopoietic systems. perform blood counts, including platelet counts

Fertlity impairment- consider the possible effect of fertility , amennorhoea and impaired spermatogenesis have occurre following therapy with alkylating agents

Pregnancy- Do not use nitogen mustard during pregnancy

Dosages/ Overdosage Etc:

Pallliative treatment of symptomatic chronic lymphocytic leukemia Non - Hodgkins lymphomas A single weekly dose of 0.15mg/kg for 4 weeks

Children- a single weekly dose of 0.3mg/kg for 4 weeks If response occurs, continue the same weekly dose until relapse

Patient Information:

1. May cause nausea, vomiting, or diarrhea, notify physician if these effects persist

2. Notify doctor of unusal bleeding or bruising , fever, chills, sore throat, cough,

shortness in breath, seizures, lack of menstrual flow, unusual lumps, or masses,

flank, joint or stomach pain, sores in mouth or on lips, yellow discoloration

of skin/eyes

Ref - USP PDI Vol II 17th Edition (1997)

URACIL MUSTARD - SYSTEMIC

1.Allergies-

Tell your doctor if you have ever had any unusual or allergic reaction to

Uracil mustard.

2.Pregnancy-

Tell your doctor if you are pregnant or intend to have children. This medicine

may cause birth defects if either the male or female is taking it at the time of

conception or it is taken during pregnancy. Also many cancer medicines may

cause sterility which could be permanent.

Tell your doctor right away if you think you are pregnant or you become

pregnant while taking this medicine.

3. Breast-feeding-

Tell your doctor if you are breast feeding or if you intend to breast feed during

treatment with this medicine. Breast feeding is not generally recommended

while you are taking it.

4.Children-

Although there is no specific information about the of uracil mustard in children,

it is not expected to cause different side effects or problems than it does in adults.

5.Older adults-

There is no specific information about the use of uracil mustard in the elderly

6. Other medicines-

When you are taking uracil mustard, it is especially important that your doctor

know if you are using any of the following medicines.

Amphotericin or

Antithyroid agents or

Chloramphenicol or

Colchicine or

Flucytosine or

Interferon or

Pilcamycin or

Zidivudine - uracil mustard may increase the concentration of uric acid in the

blood, which these medicines are used to lower

7. Other medical problems-

The presence of other medical problems may affect the use of uracil mustard.

Make sure you tell your doctor if you have any other medical problems

especially-

Chicken pox or

Herpes zoster or

Gout or

Kidney stones - uracil mustard may increase levels of uric acid in the body,

which can cause gout or kidney stones

Infection - uracil mustard can reduce immunity to infection

Kidney disease

Liver disease

Pregnancy and lactation:

Pregnancy- Do not use nitogen mustard during pregnancy

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Disclaimer: Every effort has been made to ensure that the information provided in this Database is authentic and accurate. Commissions or omissions in the database, if any, are purely inadvertent and the site owner shall not accept any liability whatsoever for any adverse consequences of any nature arising to any individual or third party, as a result of usage of this information.