Hydroxychloroquine sulfate @ Antirheumatic Agents(Jan 2008)

Drug Name:
Hydroxychloroquine sulfate @ Antirheumatic Agents(Jan 2008)

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Drug Interaction

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Drug Interaction:

Digoxin

Concurrent administration of hydroxychloroquine and digoxin has been reported to increase serum digoxin levels. Monitor digoxin levels. Hydroxychloroquine sulphate may also be subject to several known interations of cholroquine even though reports have not been recorded.

These include- - potentation of its direct blocking at the neuromuscular nunction by aminoglucosides antibiotcs - inhibition of of its metabolism by cimetidine which may increase plasma conc. of antimalarial - antagonism effect of neostigmine & pyridostigmine , - reduction of antibody response to primary immunisation with intradermal human-diplod cell rabies vaccine Antacids may reduce absorption of hydroxychloroquine so it is advised that a 4 hour interval be observed between hydrxychloroquine and antacid dosing Concurrent use of penicillamine with hydroxychloroquine may increase penicilamine plasma conc. increasing the potential for serious hematological and or renal adverse reactions as well as severe skin reactions