Cimetidine increases serum con. Absorption impaired by Mag trisilicate, pethidine, morphine,atropine Absorption enhanced by metoclopromide and Alum hydroxide. Potentiates action of major neurtoleptics Barbiturates reduce plasm levels thereby reduce antidepressant effect Cimetidine elevates serum iimipramine conc, and consequently adverse effects. Cause drowsiness and impaired performance in combination with alcohol Imipramine- Sever HTN with adrenaline noeadrenaline & methylphenindate Reveres hypotensive effects of guanethedine, betaanidine,debrisquinine & bretylium Interferes with antihypertensive action of methyl dopa @7 clonidine Reduction in seizure threshold , anticonvulsant dose needs to be increased

Depression associted with anxiety Dosage to be determined individually Usually 1 tablet thrice daily with gradual increments at weekly intervals till required Max daily dose 8 tabs Maint- minimum therapy

Physical and pscthological dependence Withdrawl syndrome Impairs psychomotor performance More accident prone Aggression in combination with alcohol in predisposed individuals esp in combination with alcohol Sedation, sinus bradycardia AV/ bundle/branch block Postural hypotension Dry mouth, weight loss/ gain Urinary hesistency/retention Impotence, blurring of vision, Excaberation of glaucoma, liver dysfunction, Eosinophillia, leucopenia, tremors

Hypersensitivity to benzodiazepines. Jaundice, myathenia gravis, respiratory depression, Porphyria, depression Post MI , heart block/arrhythmias Mania, severe hepatic impairment, Pregnancy, lactation Special precautions- Alcohol, dedation, dependance epilepsy, cardiac disease, Elderly, debilitated patients Chilkdren, withdrawal should be gradual

Depression associted with anxiety Dosage to be determined individually Usually 1 tablet thrice daily with gradual increments at weekly intervals till required Max daily dose 8 tabs Maint- minimum therapy

Contraindicated for use during pregnancy and lactation. Observe caution and use only if required.