May increase serum concentration with moderate and strong CYP3A4 inhibitors. May increase serum levels of Simvastation,lovastatin, immunosuppressants eg ciclosporin,lacrolimus

indication-

hypertension

Significant worsening angin, ,acute MI, refkex tachcardia,symptomatic hypertension

Cardiac disorder-dyspmoea

Gastrointestinal disorders- abdominal pain

Metabolism and nutrional disorders- perpipheral edema

Musculoskeletal disoder-muscle cramps

Nervous disorders- dizziness,extrpyrimidal symptoms

Reproductive system- sexual dysfunction

Skin and tissue disorders-rash,puritus

Vascular- flushing

Dosage-

Hypertension- Adult- as monotherapy or in combination- 2.5mg once daily, may increase dosage (or titrate every 1-2 week asnecssary

Maximum- 5mg once daily

Child- 6-17 years- 1.25- 2.5mg once daily

Elderly- 1.25mg once daily may increase as necessary ccording to patient resonse 

Patients with severe aoritic sterosis, severe obstructive coronry artery disease,hear failure,with reduced ejection fraction, hypertropic fraction,hypertrophic crdiomyopathy and outfllow tract obstruction.Hepatic impairment