CNS depressant drugs eg. narcotics and barbiturates,general anesthetics, exert  CNS additive effects. Individualise dose regimen.
Atropine, scopolamine and succinyl choline; Use cautiously. Tachycardia, fall in blood presure may occur.

Undesirable CNS effects such as stimuation, delirium, and extra pyramidal symptoms may be aggrevated.

 

Relief of moderate to marked pain.

Orthostatic hypotension,including fainting and syncope and weakness.
Disoreintation, dizziness, excessive sedation, weakness, slurring of speech.
 Abdominal discomfort, nausea,vomiting.
Difficult  urination.
Chills, dry mouth, nasal congestion,

 

Concurrent admin with antihypertensive agents including MAO inhibitors;

History of phenothiazine hypersensitivity;

Presence of overdose of CNS depressant or comatose states.

Severe myocardial, renal or hepatic disease.

 

Indications:  
Relief of moderate to marked pain.

Dosage:
Administer by deep IM injection into large muscle mass. Do not administer as Sc as loca
 irritation may occur. Do not administer as IV.
Adult- 10 to 20 mg(0.5 to 1 ml) IM every 4 to 6 hours as required
Elderly- initial dose of 5 to 10 mg. Increase gradualy if needed..

 

CHLOPROMAZINE-  PHENOTHIAZINES GROUP-

ALSO APPLIES TO-     ACETOPHENAZINE, CHLORPROMAXINE, FLUPHENAZINE, MESORIDAZINE,
                                 METHOTRIMEPRAZINE, PERIXYAZINE, PERPHENAZINE, PIPOTIAZINE,
                                 PROCHLORPERAZINE, PROMAZINE,  THIOPROPAZINE, THIOPROPAZATE,
                                 THIOPROPERAZINE, THORIDAZINE, TRIFLUOPERAZINE,  TRIFLUPROMAZINE

REFER - CHLORPROMAZINE
 

Pharmacology:
A phenithiazine derivative and potent CNS depressant which produces supression of sensory impulses, reduction of motor activity, sedation and tranquiliasation

Pharmacokinetics:
Peak plasma concentrations occur 30 to 90 minutes after injection. Maximum analgesic effect usually occurs within 20 to 40 minutes after IM injection and is maintained for about 4 hours.
Methotrimeprazine  is metabolised into sulfoxides and glucuronic conjucates and excreted in urine. Elimination into urine usually continues for several days after IM administration is discintinued.

 

Pregnancy:
Use with caution in women of childbearing potential and during early stages of pregnancy.

Children-

Do not use in children bolw 12 years, as safety and efficacy have not been established.