Guanethidine sulp@( *** ) - Antiadrenergic agen -Perip act

Drug Name:
Guanethidine sulp@( *** ) - Antiadrenergic agen -Perip act

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Interaction with Food

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Drug Interaction:

 Antiadrenergic agents ( Peripherally acting )include- Reserpine, Guanithidine monosulphate, Guandrel sulfate, ( Alpha-1- blockers), Prazosin,Terazosin, Doxazosin, Tamsulosin, Silodosin, Alfuzosin Hcl Refer - Prazosin 

Interacting drugs 

with Guanethidine -

 Anorexiants-                                                                                                                        the hypotensive effects of guanethidine may be reversed

Haloperidol-                                                                                                                       haloperidol antagonizes the hypotensive efect of guanethidine

Methylphenidate-                                                                                                            hypotensive effects of guanethidine may be impaired. arrhythmias were reported in one case

Minoxidil-                                                                                                                          Admin of minodixil to patients on guanithedine can result in profound orthostatic effect. Discontinue guanethidine well before mixodil is begun, if possible. If not possible, hospitalize patient when starying minoxidil.

Mephantermine-                                                                                                      antihyperstensive effects of guanethidine or reserpine may be partially or totally reversed by the mixed acting sympathomimetics

MAO inhibitors-                                                                                                                   Discontinue atleast 1 week before starting guanethedine therapy. 

Phenothiazines-                                                                                                                      the hypotensive efect of guanethidine is inhibited

Sympathomimetics with - guanethidine                                                                                     the hypotensive effect of guanethidine may be reversed, also

Guanethidine with-Sympathomimetics-                                                                       guanethidine potentiates the effects of direct acting sympathomimetics 

Thioxanthenes-                                                                                                                    the hyptensive efect of guanethidine is antagonised.

Tricyclic antidepress-                                                                                                             the hypotensive action of guanethidine is inhibited

Digitalis-                                                                                                                            Digitalis and guanethedine both slow down heart rate. 

Antidiabetic agents-                                                                                                      Guanethedine posseses antidiabetic activity.Monitor patients on altered hypoglycaemic effects. 

Tricyclic antidepressants, phenothiazines,thioxanthenes, haloperidol and indirect-acting sympathomimetics and oral contraceptives-                                                               may reduce antihypertensive effect of guanethedine. 

Metraminol-                                                                                                                   antihypertensive effects of guanethidine may be partially or totally reversed by the mixed-acting sympathomimetics 

Guanethidine with Isoproterenol-                                                                        guanethidine may increase the pressor response of the direct-acting vasopressors, possibly resulting in severe hypertension

Dobutamine-                                                                                                                   guaniethidine may increase pressor response to direct acting vasopressors, resulting in severe hypertesion

Dopamine-                                                                                                                    antihypertensive rffects of guanethidine may be partially or totally reversed by mixed-acting sympathomimetics

Epinephrine-                                                                                                          guanithedine may increase the prssor response of the direct-acting vasopressors, possibly resulting in severe hypertension

Guanethidine Direct) incr guanethidine potentiates the effects of the direct acting agents with nasal

Mixed )-                                                                                                                      epinephrine) and inhibits the effects of the mixed acting agents nasal  deconges ) ephedrine ) Guanethidine hypotensive acton may also be reversed