Drug Interaction:
In combination potassium losing diuretics(thiazide), hypokalemia or hypercalcinuria enhanced. Additive effect with other antihypertensive agents without potentiating side effects.
Indication:
New drugs approved For Marketing by Drug Controller General of India(DCGI )
during the period January 1988 to November 2014
(Ref- IDMA Annual Publication 2015)
Name of Drug Indication Date of Approval
Indapamide SR 1.5mg/1.5mg 12-05-2010
+ Nebivolol 2.5mg/5mg tablet
For the treatment of hypertension not controlled with montherapy
FIXED DOSE COMBINATIONS APPROVED BY DCG(I)
FROM JANUARY 1961 TILL NOVEMBER 2014
Name of Drug Indication Date of Approval
1.Each film coated tablets contain;
Indapamide USP (as sustained release release form) 1.5mg+ 09-05-2014
Amlodipine Besilate IP eq. to Amlodipine 2.5mg
Addl.Stgth
For the treatment of mild to moderate hypertension in elderly
patients of age more than 65 years
2.Indapamide SR 1.5mg/1.5mg + 05-12-2010
Nevibiol 2.5mg/5mg tablet
For the treatment of hypertension not controlled with
monotherapy
3. Indapamide 1.5mg/1.5mg + 08--7-2009
Ramipril 2.5mg/2.5mg FC tablet
For the management of of hypetension in subjects not
responding to any diuretic or ace inhibitor monotherapy
Hypertension.
Thiazides and related diuretics include- Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide, Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide Refer Hydrochlorthiazide- Thiazide and related diuretics
Adverse Reaction:
Headache, dizziness, lassitude, mild hypokalemia.
Contra-Indications:
Severe renal/hepatic failure,lactation.
Special precautions: Frist trimester of pregnancy,elderly.
Dosages/ Overdosage Etc:
Indications:
Hypertension.
Dosage: Adults - 2.5mg as a single dose daily.
Patient Information:
Refer Chlorthiazide - Thiazides and related diuretics
1.Allergies- tell your doctor if you have ever had any unusual or allergic reaction to indapamide or other sulfonamide type medicines. Also tell your doctor if youare allergic to any other substances, such as foods, presrvatives or dyes.
2.Pregnancy - indapamide has not been shown to cause birth defects or other problems in animal studies.
3.Breast feeding- indapamide has not been reported to cause problems in nursing babies
4 Children - no specific information comparing use of indapamide in children with use in other age groups
5. Elderly- dizziness or lightheadedness and signs of too much potassium loss are more likely to occur in elderly.
6. Other medicines - Let your doctor know what other medicines you are taking, so that he can advice you accordingly. Digitalis glycosides - use with indapamide may increase the chance of side effects of digitalis glycosides Lithium - use with indapamide may casue high levels of lithium which may increase the chance of side effects.
7. Other medical problems - Tell your doctor if you have any other medical problems especially - Diabetes mellitus or Gout - indapamide may make these conditions worse Kidney diseasse - may prevent indapamide from working properly Liver disease - higher blood levels of indapamide may occur which may increase the chance of side effects
8. Missed dose - If you miss a dose of this medicine, take it as soon as possible. however, if it is almost time for the next dose, skip the missed dose. Do not double doses.
9. Storage - Keep out of reach of children. Store away from heat or direct sunlight. Do not store the capsule in bathroom, near the kitchen sink, or in other damp places.
10. Outdated medicines - Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of reach of children.
Pharmacology/ Pharmacokinetics:
Thiazides and related diuretics include- Bendroflumethiazide, Benzthiazide, Chlorthiazide, Hydrochlorthiazide, Hydroflumethazide, Indapamide, Methyclothizide, Metolazone, Polythiazide, Quinethazone, Trichlormethiazide Refer Hydrochlorthiazide- Thiazide and related diuretics
Interaction with Food:
None reported
Pregnancy and lactation:
Refer Chlorthiazide- Thiazides and related diuretics
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