Levofolinic acid -(BNF)- Cytotoxic drugs
Drug Name:
Levofolinic acid -(BNF)- Cytotoxic drugs
List Of Brands:
Indication Type Description:
Indication:
Ref- BNF (British National Formulary- March 2015)
Indications-
used to counteract the folate-antagonist action of methotrexate and
thus speed up recovery from methotrexate -induced mucositisis or
myelosuppression( folinic acid rescue)
Adverse Reaction:
Side effects-
rarely pyrexia after parantral use,
insomnia, agitation anddepression after high dose
Contra-Indications:
Contraindication-
intrathecal injection
Caution-
avoid simultaneous adminstration of methotrexate
not indicated for pernicious anaemias or other megaloblastic anaemias
caused by vitamin B12 defeciency reactions
Dosages/ Overdosage Etc:
Ref- BNF (British National Formulary- March 2015)
BRAND - CALCIUM LEVOFOLINATE
DISODIUM LEVOFOLINATE
MANUFACTURER - NON-PROPRIETARY
Indications-
used to counteract the folate-antagonist action of methotrexate and
thus speed up recovery from methotrexate -induced mucositisis or
myelosuppression( folinic acid rescue)
Calcium levofolinate -
Calcium folinate injection
levofolinic acid (as calcium salt) 10mg/ml
Isovorin ( PFIZER )
injection -lvofolinic acid (as calcium salt) 10mg/ml
Disodium levofolinate
Levofolinic Acid- Non-proprietary
injection -levofolinic acid (as disodium salt) 50mg/ml
dose as a antidote to methotrexate injection
adjunct to fluorouracil in colrectal cancer
Pregnancy and lactation:
Pregnancy-
not known to be harmful , benefit outweighs risks
Breast feeding-
presence in milk unknown, but benefit outweighs risks
