Decreases lovadopa effects

Effects may be enhanced by using drugs with antimuscranic properties or MAOI concurrently

May antagonise the GI effects of cisapride, metoclopramide, and domperidone

IV admin in presence of cyclopropane anesthesia can result in ventricular arrhythmias

Peptic ulcer

Xerotomia, loss of taste, nausea, vomiting, constipation, reduced sweating,

Urinary hesistency and retention,  blurred vision, cyclopegia,

Increased ocular tension, tachycardia, palpitation, headache, anxiety

Bloated feeling, impotence, skin reactions, severe anaphylaxis

Hypersensitivity
Glaucoma obstructive uropathy, obstructive GI diseases, intestinal atony

Paralytic ileus, pyloric stenosis , myastina gravis, unstable CV status in   acute haemorrhage

Injectable not recommended in new borns < 1month if benzyl alcohol present in the preparation

Special precautions-
Pregnancy, lactation.
CV disease , hyperthyroidism, hepatic or renal impairment

Enlarged prostrate, diarrhoea, fever.
May cause ileus or megacolon in patients with ulcerative colitis

Children and elderly

Indication-

Peptic ulcer

Dosage-
adult- 1-2ml bid-tid

Parentral-
Reduction of secretion
Adult-4mcg/kg via IM  admin 30-60 minutes before procedure
Introperative -.1mg via IV  admin ,repeat at 2-3 min intervals when needed

Child- preoperative IM admin < 2 year - 4-9 mcg/kg .
> 2 yr 4mcg/kg dose to bengiven 30-60 min before procedure.

Intraoperative -  IV  admin 4mcg/kg ( Max 0.1mg ) repeat at 2-3 min interval as needed.
Max dose- adult 400mcg/dose  child > 1 month 200mcg/ dose

Peptic ulcer- Adult- 0.1 -0.2 mg 3-4 times daily via IM/IV  admin
 

Use contraindicated . Excercise caution if use is required