Galantamine Hydrobromide - @ - Cholinesterase Inhibitors
Drug Name:
Galantamine Hydrobromide - @ - Cholinesterase Inhibitors
List Of Brands:
Indication Type Description:
Drug Interaction:
Drug interactions - summary-
Cimetidine + galatamine-
cimetidine increased bioavailability of galatamine
CYP2D6 or CYP3A4 inhibitors + Galatamine -
drugs that are potential ihibitors of CYP2D6 or CYP3A4 may icrease AUC of galatamine
Erythromycin + galatamine-
erythromycin increased AUC of galatamine
Ketoconazole + galatamine-
Ketoconazole increased AUC of galatamine
Paroxetine + galatamine-
paroxetidine increased oral bioavailability of galaamine
Galatamine + anticholinergics -
galamine has the potential to intefere with activity of anticholinergic medications
Galatamine + neuromuscular blocking agents -
galatamine may exaggerate the neuromuscular blockade effects of neuromuscular
blocking agents during anesthesia
Galatamine + NSAIDs-
galatmine may increase gastric secretion because of inceased cholinergic activity.
Monitor patients for symptoms of active or ocult GI bleeding
Galatamine + succinyl cholinergic agonists( eg bethanectol) other cholinersterase inhibitors/
Succinyl cholinergic agonists( eg bethanectol) other cholinersterase inhibitors + Galatamine-
a synergic effect is expected when combined
Indication:
Alzheimers disease
Adverse Reaction:
Most serious adverse drug reactions -
CNS - depression 6% dizziness 8% headache 7% insomnia 4%
somnolence 3% tremor 3%
GI - abdominal pain 4% anorexia 8% diarrhea 8% dyspepsia 4%
nausea 23% vomiting 12%
GU - hematuria 2% urinarybtract infection 7%
Miscellaneous- anemia 2% bradycardia 2% fatigue 4% rhinitis 4%
syncope 2% weight decrease 6%
Contra-Indications:
Known hypersensitivity-
Special precautions-
Anesthesia- galatamine as a cholinesterate inhibitor is likely to exaggreate the neuromuscular
effect of succinyl choline type and similar neuro-muscular blocking agents during anesthesia
Cardiovascular conditions- bradycardia and all types of heasrt block have been reported
with or without underlying cardiac conduction abnormalities. Consider all patients are
at risk of adverse reactions on cardiac conduction.
Pulmonary conditions- prescribe galatamine with care to patients with a history of severe
asthma or obstructive pulmonary disease
Renal function impairment - in patients with severe renal function impairment proceed cautiously
with dose totration. Do not exceed a dose of 16mg/day
Hepatic function impairment- use of galatamine in patients with severe hepatic impairment
is not recommended
Pregnancy- use galatamine during pregnancy only if the potential benefit justifies the potential
risk to the fetus.
Lactation-galatamine has no indication for use in breast feeding mothers
Children- use of galactamine in children is not recommended
Monitoring- monitor patients for symptoms of active or occult GI bleeding especially those
with increased risk of developing ulcerseg history of ulcer disease
Dosages/ Overdosage Etc:
Indication-
Alzheimers disease
Dosage-
usual dosage- 16 to 32mg given twice daily. 32mg/ day dose is not as well tolerated
as the lower doses and does not provide increased efficacy
Possible that a daily dose of 24mg/ day might provide benefits insome persons
Administer galantamine twice daily preferably with morning and evening meals
Patient Information:
1. Administer galatamine ER capsules once daily in the morning preferably with food.
2. Advice patents that most frequent adverse drug reactions can be be minimized by
following the recommended dosage and administration.
Interaction with Food:
Administer galantamine preferably with morning and evening meals
Pregnancy and lactation:
Pregnancy-
Use galatamine during pregnancy only if the potential benefit justifies the potential
risk to the fetus.
Lactation-
Galatamine has no indication for use in breast feeding mothers
Children-
Use of galactamine in children is not recommended