Perindopril Erbumine + Amlodipine Besilate
Drug Name:
Perindopril Erbumine + Amlodipine Besilate
List Of Brands:
Indication Type Description:
Pharmacology/ Pharmacokinetics
Adverse Reaction:
Headache, somloence,
Nausea
Abdominal pain, dyspepsia
Palpitations, dizziness
Contra-Indications:
In children, pregnancy, lacating women
Patients sensitive to the product
Dosages/ Overdosage Etc:
Indication-
Hypertension
Dosage-
I tablet daily at breakfast
Pharmacology/ Pharmacokinetics:
Rationale for combination-
International guidelines have strongly endorsed fixed -dose combinations for first-line and
second line treatment of hypertension
ACE inhibitors and CCB combinaton stand out among recommended combinations for either
complementary mechansims of action which lead to enhanced efficacy
The Anglo-Scandinavian cardiac outcomes Trial Blood Pressure Lowering Arm ( ASCOT- BPLA )
trail demonstrates a significant reduction in risk of cardiovascular and all-cause death, stroke,
coronary events, and procedures, new onset diabetes and new onset renal impairment with
combination with amlodipine and peridopril in a wide range of patients with hypertension.
Amlodipine and perindopril is an ideal evidence based combination in the treatment
of hypertension
Pregnancy and lactation:
Contraindicated in pregnancy and lactation.
Observe caution if use is required.