Drug Interaction:
Drug interactions- summary
Barbiturates reduce antidepressant effect of dosulepin
Raised erun concentration with with methylphenidate .
Cigarette smoking enhances metabolism.
Increased risk of ventricular arrhthymias when used with drugs that prolong QT intervals
Should not be given concurrently or within 14 days of stopping MAOIs .
Potentiates catecholamine, sympathomimetics , narcotics, and alcohol
Reduce hypotensive activity of bethanidine , guanethidine
Indication:
New Drugs Approved by (DCI) Drug Controller GENERAL - India For Marketing
(Ref- IDMA Publication)
Name of Drug Indication Date of Approval
1.Dousulepin Hcl Tablet 08-04-2010
25mg/75mg
Addl.indication
For the treatment of chronic pain
2. Dosulepin Hcl 50mg/75mg + 08-12-2011
Methyl Cobalamine 1500mcg/ 1500mcg
Tablets
For the treatment of neuropathic pain
Depression
Adverse Reaction:
Cholestic jaundice, sexual dysfunction, exacerbation of psychotic manifestation,
cardiac arrhthymias, hypotension, dry mouth, constipation, disturbance of accomodation,
tachycardia, postural hypotension, drowsiness, tremors, and skin rash
Withdrawal symptoms with abrupt cessation, insomnia irrirability, and excessive sweating
Bone marrow depresson, cardiac arrhythmias, and agranulocytosis.
Reports of ventricular fibrilation and renal failure
Contra-Indications:
Hypersensitivity, recent MI , neonate heart block, cardiac arrhythmias, mania,
alcohol, other CNS depressants,
Severe liver disease, prostate disease, children
Special Precautions-
Epilepsy, hypotension, glaucoma, urinary retension, gradual withdrawal,
Pregnancy, Lactation, elderly
Dosages/ Overdosage Etc:
Date of Approval 2010
For the treatment of neuropathic pain
Indication-
Depression
Dosage-
Adult- initially 25mg tid, gradually increased to 50mg tid if necessary,
alternately as a single dose at night.
Upto 225mg/day may be used in severe depressin.
Elderly- initially 50- 75mg daily
Pregnancy and lactation:
Contraindicated for use during pregnancy
