Thioridazine Hydrochloride - Sedatives and Tranquilizers

Drug Name:
Thioridazine Hydrochloride - Sedatives and Tranquilizers

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Patient Information

Pregnancy and lactation

   

Drug Interaction:

Drug interactions- summary-

Potentiates adverse effects of anticholinergics.

Concurrent use of TCAs leads to raised blood levels of both drugs

May antagonise  effects of levodopa , bromocriptine, and other dopamine antagonists

Avoid coadmin with drugs that cause electrolyle imbalance. 

Monitor phenytoin therapy due to inconsistent  effects of thioridazine on phenytoin levels.

Increased risk of QT prolongation  with class Ia, Class II  antiarrhythmics , astemizole,
cisapride, pimozide, droperidol, erythromycin IV, sparfloxacin, terfenadine, clarithromycin,
and other drugs that may prolong QT intervals

Potentiates CNS depression with opioids, .

Increased risk of arrhyhthmias with ephedrine-like drugs, eg phenylpropanolmine

Increased  risk of thioridazine levels with fluovoxamine, pinadol, propranol, ritonavir and
other CYP2D6 isoenzyme inhibitors eg. fluoxetine, paroxetine