Thioridazine Hydrochloride - Sedatives and Tranquilizers
Drug Name:Thioridazine Hydrochloride - Sedatives and Tranquilizers
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Patient Information
Pregnancy and lactation
Drug Interaction:
Drug interactions- summary-
Potentiates adverse effects of anticholinergics.
Concurrent use of TCAs leads to raised blood levels of both drugs
May antagonise effects of levodopa , bromocriptine, and other dopamine antagonists
Avoid coadmin with drugs that cause electrolyle imbalance.
Monitor phenytoin therapy due to inconsistent effects of thioridazine on phenytoin levels.
Increased risk of QT prolongation with class Ia, Class II antiarrhythmics , astemizole,
cisapride, pimozide, droperidol, erythromycin IV, sparfloxacin, terfenadine, clarithromycin,
and other drugs that may prolong QT intervals
Potentiates CNS depression with opioids, .
Increased risk of arrhyhthmias with ephedrine-like drugs, eg phenylpropanolmine
Increased risk of thioridazine levels with fluovoxamine, pinadol, propranol, ritonavir and
other CYP2D6 isoenzyme inhibitors eg. fluoxetine, paroxetine