Oral  diabetic agents,    ACE inhibitors, disopyramide,  fibrates

Fluoxetine, MAOIs ,   pentoxyphylline,  propoxyphene, salicylates, danazol,

Sulphonamide antibitics,  diazoxide,   corticosteroids,  diuretics, glucagon,

Isonazid , oestrogens and progestogens,  phenothiazine derivatives,

Somatropin,  sympathomimetic agents, (eg adrenaline, ephinephrine, )

Salbutamol,   terbutaline,  Thyroid hormones,  alcohol,   beta-blockers,

Clonidine, lithium salts,  pentmidine, guanithedine,  reserpine,

Nifedipine,  angiotensin II antagonists, octrotide, pioglitazone

INFORMATION UP DATE-

INSULIN GLARINE-

A German Study of 1.27,000 diabetic patients has found that those who use Lantus are at
an increased rate of developing cancer compared to others who use human insulin

Out of every 100 patients who use Lantus over a period of 18 months , one additional  person
may suffer from malignancy . The risk is dose dependent , higher the dose higher the risk of
cancer.

Patients who receive 10 units have 9% increased risk compared to 31% when the dose is increased
to 50 units - ( MIMS )

Hypoglycaemia,  temporary visual impairment

Injection site reactions including lipodstrophy,

Priritus, rash,

Possibility of increased risk of cancer

Sports events-  restricted /banned
 

Hypersensitivity to insulins

Special precautions/Warnings-

Patients transferred to human insulin should be adviced that the early warning symtoms
of hypoglycemia may be less pronounced than with insulins from an animal source

Change in strength, brand, type, origin  and or method of manufacture may require
change in dosage.

Dose changes may be required with infectin, stress, excercise , trauma, surgery,
and at puberty

Renal or hepatic impairment,

Not the insulin of choice in diabetic ketoacidosis

 Pregnancy, lactation

Indication-

Diabetes

Dosage-

By s.c. once daily at the same time each day

Dosage according to requirement . Duration approximately 24 hours .

Not recommended for children below 6 years.

Excercise cautiion while administering during pregnancy and lactation.