Bortezomib -Velcade(2003)- @ -Proteasome Inhibitors - Antineoplastic Agents
Drug Name:Bortezomib -Velcade(2003)- @ -Proteasome Inhibitors - Antineoplastic Agents
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Patient Information
Pregnancy and lactation
Drug Interaction:
Oral hypoglycemcis Cytarabine, Inhibitors of CYP3A4 or 2C 19 Ketaconazole, Amiadarone, antivirals, isoniazid Metronidazole, statins, Nitrofurantoin, Hypotensives
Indication:
Adverse Reaction:
Peripheral neuropathy, pain polyneuropathy rash,myalgia myopathy, arthalgia, anorexia infections insomnia, anxiety , depression tinnitus, dizzines, vertigo taste disturbances blurred vision, eye pain
Contra-Indications:
Severe hepatic impairment
Acute diffuse infiltrative pulmonary and pericardial disease
Pregnancy Lactation
Special precautions-
Renal or hepatic impairment
Amyloidiosis
Risk of haematological toxicites particularly thrombocytopenia
Monitor and platelet counts throughout treatment
Monitor patients who experience constipation
Risk of pulmonary disease perform pretreatment chest X RAY and monitor for new or worsening symptoms
Dosages/ Overdosage Etc:
Indication-
Monotherapy for treatment of progressive multiple myeloma
Dosage-
Given as 3-5 second IV bolus inj
Previously untreated multiple myeloma - treat for nine- 6 week cycles in combination with oral melphalan and oral prednisolone
Patient Information:
Bortezomib-
1. Bortezomib may cause fatigue, dizziness, syncope, and orthostatic /postural hypotension.
Advice patients not to drive or operate machinery if they experience these symptoms.
2. Advice patients to take appropiate measures if they experience vomiting/and/or diarrhea, to
avoid dehydration
3. Advice patients to seek medical advice if they experience light headedness, dizziness, or
fainting spells.
4. Advice patients to use effective contracepives measures to prevent pregnancy and to
avoid breast feeding during treatment with bortezomib
Pregnancy and lactation:
Use contraindicated Observe caution