Drug Interaction:
Gatifloxin
It interacts with aluminium or magnesium salts or ferrous sulphate or dietary supplements containing zinc ,magnesium, or iron.
Therefore it should be taken 4 hours before antacids Concomittant administrstration of nonsteroidal anti0inflammatory drugs with a quinolone may increase the risks of CNS stimulation and convulsions although not observed with gatifloxacin in preclinical and clinical trials.
Indication:
Sinusitis Diarrhoea due to mixed infections Dental infections Gynaecological infections
Adverse Reaction:
Nausea,diarrhea, Headache, dizziness, Abdominal pain, Vertigo, skin rash, and headache.
Contra-Indications:
Gatifloxacin
Gatifloxacin is contraindicated in children less than 18 years old and in pregnant or nursing women due to arthopathies and cartilage damage associated with the drug class.
Gatifoxacin may potentially prolong QTc interval and should be avoided by patients with known prolongation of the QTc interval, patients with unconnected hypokalemia and patients receiving class IA e.g. quinidine, procainamide or class III (eg. amiodarone, solatol, antiarrhythmic agents It should be used with caution in combination other drugs that can prolong the QTc interval such as ( cisapride, erythromycin, tricyclic antidepressants and antipsychotics) and in patients with prior -rhythmic conditions such as bradycardia, or acute myocardial ischemia.
Dosages/ Overdosage Etc:
Indication-
Sinusitis, Diarrhoea due to mixed infections, Dental infections, Gynaecological infections
Dosage-
400mg once daily
Pharmacology/ Pharmacokinetics:
Pharmacology-
Gatifloxacin acts by the inhibition of DNA gyrase and topoisomerase IV. DNA gyrase Topoisomerase IV are essential enzyme required for replication and partioning of the replicated chromosome during bacterial cell divison.
Omidazole is ameobicidal, bactericidal and trichomonicidal. Anaerobic organisms readily take up inionized omidazole.
These organisms reduce omidazole to its active form intracelluluraly by the reduction of the nitro group to an anion radical. The anion radical is highly reactive and wil form adjuncts with proteins and DNA leading to inhibition of bacterial neucleic acid synthesis.
Pharmacokinetics-
Gatifloxacin is well absorbed after oral administration. Its absolute bioavailability is approximately 96%.
The drug acheives maximun plasma concentrations in 0.75 - 2 hours (Tmax) after administration of doses from 200 - 800mg with or without food, milk, or tea, has little apparent effect on drug absorption Omidazole is well absorbed after oral administyration. Biovailability is at least 90%. Food decreases the rate but not the extent of absorption.
Omidazole is metabolised in the liver by hydroxylation, oxidation, and glucoronide conjugation. The plasma elimnation half life of omidazole is 12 to 14 hours. Both unchanged drug and metabolites are excreted in the urine and feces.
Interaction with Food:
Gatifloxin interacts with aluminium or magnesium salts or ferrous sulphate or dietary supplements containing zinc ,magnesium, or iron.
Therefore it should be taken 4 hours before antacids Omoidazole- Food decreases the rate but not the extent of absorption.
