Reports not available

Acute painful spasmodic conditions Smooth muscle spasms

Dry mouth, nausea, bloating, dizziness, headache, drowsiness, confusion, dyskinesia, insomnia blurring of vision, increased intraocular tension,rash, urticaria, urinary hesistency, dyspnoea, peptic ulceration, tinnitus, leukopenia, thrombocytopenia, anaphylaxis, blood dyscrasias and abonormal liver function tests.

Known allergic to any of the ingredients. In patients allergic to aspirin and other NSAIDs severe anaphylactic reactions have been reported. Obstructive uropathy or any obstructive GI disease, severe ulcerative colitis, unstable cardiovascular status in acute hemorrhage, glaucoma, myasthenia gravis

Special precautions- Should not operate machinery or drive after injection. CNS signs andsymptoms may be seen as confusion, hallucination etc. which resolve usually in12 to 24 hours of drug discontinuation. It should be given with care to patients with peptic ulceration,a history of such ulceration and in those who are receiving coumarin anticoagulants.

Close monitoring of advanced renal disease patients on diclofenac therapy should be done. Care to be excercised in patient with bronchial asthma.

Caution to be excercised in patients with hepatic/renal disease hyperthyroidism, hypertension, coronarty heart disease,congestive hearat failure ,cardiac tachycardia etc.

Indications

Acute, painful spasmodic conditions. acute colicky pain due to renal calculi, general colic in abdomen, spasmodic dysmenorrhea.

Dosage

2ml by IM route. Max dose should not exceed 3amp . Follow up with siutable oral therapy. Long term injectable therapy not advocated.

Pharmacology

Diclofenac is a potent NSAID with an analgesic and antipyretic properties. Diclofenac acts by inhibiting cyclo-oxygenase activity therby decreasing the synthesis of prostaglandins ,prostacyclin and thromboxane. In addition it appears to reduce intracellular concentrations of free arachiodonate in leukocytes , perehaps by altering the release or uptake of the fatty acid. Camylofin a smooth muscle relaxant with both anticholinergic action as well as direct smoth muscle action. Anticholinergic action is produced by inhibiting the binding of acetylcholine to muscarinic receptors, but the action is less pronounced. Direct smooth muscle relaxation is acheived by inhibiting phosphodiesterase type IV, which leads to increased cyclic AMP and eventually reduced cytosolic calcium. Thus Camylofin has a comprenhensive action to relieve smooth muscle spasm. Combination of diclofenac sodium and camylofin dihydrocholride may be useful in relieving colicky pain arising from spasms of smooth muscle.

Reports not available

Reports not available