Reduced levels /effects with antacids, phenobarbital , carbamazepine, aminogluthimide, phenytoin, rifampicin, naficillin, nevirapine, omeprazole,

Increase serum levels/effects with azole antifungals agents, cimetidine, efavirenz,

Increased serum levels/effects of azithromycin, ca chanl blockers, clarithromycin, corticosteroids ( eg, fluticasone), mitrazipine, nateglinide, nefazodone, cyclosporin

HIV infection

Hyperglycemia, dyslipdaemia, and redistribution of body fat , buffalo hump, facial atrophy, and heart engorement, Hypertriglyceridaemia, diarrhoea, rash, nausea, Flatulance, decreased lymphocytes, Decreased neutrophils,

Decreased haemoglobulin, Increased creatinine kinase, Increased transaminases

Hypersensitivity Lactation Severe hepatic impairment

Special precautions-

Pregnancy Interupt treatment if severe hepatotoxicity or life-threatening skin reactions develop. Renal or hepatic insufficiency

Monitor liver function periodically

HIV infection combined or other antiretroviral

Dosage-

1.25g bid or 0.75g bid child- combined - 2-13yr - 45-55mg bid or 24-35mg /kg tid max dose 0.75g

Use contraindicated. Observe caution