Quetiapine- Antipsychotic agent -Dibenzepine derivative- (May 2002)
Drug Name:Quetiapine- Antipsychotic agent -Dibenzepine derivative- (May 2002)
List Of Brands:
Indication Type Description:
Drug Interaction
Indication
Adverse Reaction
Contra-Indications
Dosages/ Overdosage Etc
Pregnancy and lactation
Drug Interaction:
Increased risk of drowsiness and postural hypotension when used with alcohol CYP3A 4 inducers eg phenytoin & carbamazepine may increase plasma levels of quetiapine while CYP3A4 inhibitors eg ketoconazole and erythromycin may increase plasma levels.
Indication:
Adverse Reaction:
Headache, asthenia, abdominal pain back pain, fever, chest pain postural and orthostatic hypotension, hypertension, constipation, dry mouth, dyspepsia, diarrhoea leucopenia, elevation in serum transaminase level, weight gain, myalgia, somnolence, dizziness, anxiety rhinitis, rash, dry skin, ear pain, UTI, syncope, neuroleptic malignant syndrome, variations in WBC count neutropenia, eosinophilia, elevation in nonfasting serum TG Level and total cholesterol decrease in thyroid horme levels, prolongation of QTc intervals
Contra-Indications:
Severe CNS depression, bone marrow supression
Special precautions-
CV disease, cerebrovascular disease or conditions that predispose to hypotension
History of seizures, neuroleptic malignant syndrome, tardive dyskinesia
Monitor glycaemic control esp in diabetics
Hepatic or renal impairment Gradual withdrawal is recommended
Monitor for signs of clinical worsening, suicidallity or unusual changes in behaviour
Pregnancy and Lactation
Dosages/ Overdosage Etc:
Dosage-
Adult- 25mg bid on day
1 increased to 50mg bid on day
2 100mg on day
3 150mg on day
4 Usual dosage range- 300mg - 450mg daily Max - 750mg /day
Elderly - initially 25mg daily increased in steps of 25- 50 mg daily daily according to response
Pregnancy and lactation:
Contraindicated for use during pregnancy and lactation Use with caution