Nondepolarizing Neuromuscular Blockers include-

Pipercuranium, Vecuronium,Doxacuranium, Tobocurane, Mivacuranium,Rocuronium, Cisatracurarium, Atracurarium,Pancuronium

Refer- Pancuronium

 Anticonvulsant- resistence to neuromuscular blocking action of nondepolarizing agents has been demonstrated Isoflurane or enflurane-

when administered with nitrous oxide/oxygen may prolong clinically effective duration of action

Succinylcholine- time to onset of action is faster following with prior administration of succinylcholine

Adjunct to general anaesthesia

 Nondepolarizing Neuromuscular Blockers include-

Pipercuranium, Vecuronium,Doxacuranium, Tobocurane, Mivacuranium,Rocuronium, Cisatracurarium, Atracurarium,Pancuronium

Refer- Pancuronium

Bradycardia, hypotension, flushing, bronchospasm, rash.

Hypersensitivity to the drug

Special precaution:

Endotracheal intubation.

Neuromuscular diseases,

Burns.

Indication-

Adjunct to general anaesthesia

Dosage:

Administer IV only

Overdosage- Symptoms

Extended skeletal muscle weakness, decreased respiratory reserve, lower tidal volume, prolonged apnea, cardiovascular collapse and sudden release of histamine. sufficiently excessive . doses of nondepolarizing muscle relaxants have no antidote.

Treatment

1. A peripheral nerve stimulator may be used to assesss the degree of residual neuromuscular blockade

2. For residual neuromuscular blockade with respiratory paralysis or inadequate ventilation, maintain airway and administer manual or mechanical ventilation.

 Missed dose-

 1. If you miss a dose of this medicine, take it as soon as possible.

2. However, if it is almost time for next dose, skip the missed dose and go back to your regular dosing schedule.

3. Do not double doses.

Pharmacology:

Cisatracurium is a nondepolarizing skeletal muscle relaxant

Pregnancy:

Use only when needed.

Lactation:

Excercise caution following administration to a nursing woman