Lovastatin( ** ) @ - HMG-CoA reducts inhibt - Antihyperlpidemic -(FDC- List)- (1989)

Drug Name:
Lovastatin( ** ) @ - HMG-CoA reducts inhibt - Antihyperlpidemic -(FDC- List)- (1989)

List Of Brands:

Indication Type Description:

Drug Interaction

Indication

Adverse Reaction

Contra-Indications

Dosages/ Overdosage Etc

Other Information

Patient Information

Pharmacology/ Pharmacokinetics

Interaction with Food

Pregnancy and lactation

   

Drug Interaction:

HMG-COA reductase inhibitors include- Fluvastatin, Lovastatin, Pravastatin, Simvastatin
Refer - Lovastatin

 Drug interactions -Summary


HMG -COA reductase inhibitors +

Warfarin   
    anticoagulant effect of warfarin may be increased. Monitor
    prothrombin time

Bile salts +   Pravastatin  
     a 40%  decrease in pravastatin bioavailability may occur. Take
     Pravastatin  1 hour before and 4 hour after bile acid sequestrant

Cyclosporine + Lovastatin 
     severe myopathy or rhabdomyolysis may occur with concurrent
      administration

Erythromycin +  Lovastatin 
     severe myopathy or rhabdomyolysis may occur with concurrent
      administration

Gemfibrozil +  HMG -CoAInhibitors    
     severe myopathy or rhabdomyolysis may occur. This has been
     reported with lovastatin. The urinary excretion and and protein
     binding of pravastin may be decreased by gemfibrozil.
      Avoid this concurrent use

Niacin +   Lovastatin 
   severe myopathy or rhabdomyolysis may occur with concurrent
     administration

 

Rhabdomylosis and acute renal failure with gemfiboz, nicotin  acid, immunosupressants,
erythromycin.
Coumarin anticoagulants- bleeding or increased prothrombin  time.
May increase the anticoagulant
effect of warfarin or anisindione due to inhibition of anticoagulants hepatic metabolism. Risk of
bleeding may be increased